Bridging Metabolome and Health
cell and bacteria 细胞和菌
cancer cell 乳腺癌细胞
Zhang J, Zhang Y, Wu W, et al. Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.[J]. Cell Death & Disease, 2017, 8(10):e3151.
Huang Q, Shen H M, Shui G, et al. Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.[J]. Cancer Research, 2006, 66(11):5807-15.
PC12 cell PC12 细胞
Guan S, Bao Y M, Jiang B, et al. Protective effect of protocatechuic acid from Alpinia oxyphylla, on hydrogen peroxide-induced oxidative PC12 cell death[J]. European Journal of Pharmacology, 2006, 538(1):73-79.
cell membrane 细胞膜
Molino D, Nola S, Lam S M, et al. Role of tetanus neurotoxin insensitive vesicle-associated membrane protein in membrane domains transport and homeostasis[J]. Cellular Logistics, 2015, 5(1):-.
Thibault G, Shui G, Kim W, et al. The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network[J]. Molecular Cell, 2012, 48(1):16-27.
macrophages 巨噬细胞
Heinz L, Baumann C, Köberlin M, et al. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity[J]. Cell Reports, 2015, 11(12):1919-1928.
Blanc, Mathieu, Hsieh, et al. The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response[J]. Immunity, 2013, 38(3):106-18.
Watterson S, Guerriero M L, Blanc M, et al. A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction[J]. Biochimie, 2013, 95(3):613-621.
Blanc M, Hsieh W Y, Robertson K A, et al. Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis[J]. Plos Biology, 2011, 9(3):e1000598.
mycobacterial 分枝杆菌
Portevin D, Sukumar S, Coscolla M, et al. Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis[J]. Microbiologyopen, 2014, 3(6):823-835.
Shui G, Bendt A K, Pethe K, et al. Sensitive profiling of chemically diverse bioactive lipids[J]. Journal of Lipid Research, 2007, 48(9):1976.
Ang M L, Zainul Rahim S Z, Shui G, et al. Erratum for Ang et al. An ethA-ethR-Deficient Mycobacterium bovis BCG Mutant Displays Increased Adherence to Mammalian Cells and Greater Persistence In Vivo, Which Correlate with Altered Mycolic Acid Composition[J]. Infection & Immunity, 2015, 83(2):1850-1859.
Low K L, Shui G, Yeo W K, et al. Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin.[J]. Journal of Biological Chemistry, 2010, 285(28):21662-70.
Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science. 2018, 362(6418).
magnaporthe oryzae
(M. oryzae)
稻瘟病菌
Xue Y, Shui G, Wenk M R. TPS1 drug design for rice blast disease in magnaporthe oryzae[J]. Springerplus, 2014, 3(1):18.
Patkar R N, Xue Y K, Shui G, et al. Abc3-mediated efflux of an endogenous digoxin-like steroidal glycoside by Magnaporthe oryzae is necessary for host invasion during blast disease.[J]. Plos Pathogens, 2012, 8(8):e1002888.
Syncytiotrophoblast microvesicles
合胞体滋养细胞微泡
Baig S, Lim J Y, Fernandis A Z, et al. Lipidomic analysis of human placental syncytiotrophoblast microvesicles in adverse pregnancy outcomes[J]. Placenta, 2013, 34(5):436-442.
Dengue virus host cells
登革病毒宿主细胞
Poh M K, Shui G, Xie X, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication[J]. Antiviral Research, 2012, 93(1):191-198.
Plasmablasts 浆母细胞
McGehee AM1, Dougan SK, Klemm EJ, Shui G,et.al.XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.The Journal of Immunology, 2009,15;183(6):3690-9.
Burkholderia pseudomallei
伯克霍尔德氏菌
Novem V, Shui G, Wang D, et al. Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis[J]. Clinical & Vaccine Immunology Cvi, 2009, 16(10):1420.
Amoeba cells
变形虫细胞
Deng Y, Almsherqi Z A, Shui G, et al. Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria.[J]. Faseb Journal, 2009, 23(9):2866-2871.
Fei W, Li H, Shui G, et al. Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.[J]. Journal of Lipid Research, 2011, 52(12):2136.
adipocytes 脂肪细胞
Gong J, Sun Z, Wu L, et al. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites[J]. Journal of Cell Biology, 2011, 195(6):953.
(Hela) / 2937 cell
人类细胞
Liao J, Guan Y, Chen W, Shi C, Yao D, Wang F, Lam SM, Shui G, Cao X. ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity. J Mol Cell Biol. 2018, doi: 10.1093.
Wang XH, Su M, Gao F, Xie W, Zeng Y, Li DL, Liu XL, Zhao H, Qin L, Li F, Liu Q, Clarke OB, Lam SM, Shui GH, Hendrickson WA, Chen YH. Structural basis for activity of TRIC counter-ion channels in calcium release. Proc Natl Acad Sci. 2019, doi: 10.1073.
Weishan Wang, Shanshan Li, Zilong Li, Jingyu Zhang, Keqiang Fan, Gaoyi Tan, Guomin Ai, Sin Man Lam, Guanghou Shui, Zhiheng Yang, Hongzhong Lu, Pinjiao Jin, Yihong Li, Xiangyin Chen, Xuekui Xia, Xueting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang, Siliang Zhang, Gil Alterovitz, Wensheng Xiang & Lixin Zhang. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. NatureBiotechnology. 2019, doi:10.1038
Streptomyces
链霉菌
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