Bridging Metabolome and Health

Human  人类

plasma 血浆

· Song JW#, Lam SM#, Fan X#, Cao WJ, Wang SY, Tian H, CHUA GH, Zhang C, Meng FP, Xu Z, Fu JL, Huang L, Xia P, Yang T, Zhang SH, Li BW, Jiang TJ, Wang RX, Wang ZH, Shi M, Zhang JY*, Wang FS*, Shui G*, Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Metabolism 2020,

· Chen, Yanxing, Lin, Caixiu, Guo, Zhangyu, Zhao, Shuai, Zhu, Yueli, Huang, Fude, Shui, Guanghou, Lam, Sin Man, Pu, Jiali, Yan, Yaping, Liu, Zhirong, Zhang, Baorong. Altered Expression Profile of Phosphatidylinositols in Erythrocytes of Alzheimer’s Disease and Amnestic Mild Cognitive Impairment Patients. Journal of Alzheimer'sDiseas. 2019, doi:10.3233

· Lu J#, Lam SM#, Wan Q, Shi L, Huo Y, Chen L, Tang X, Li B, Wu X, Peng K, Li M, Wang S, Xu Y, Xu M, Bi Y, Ning G, Shui G*, Wang W*. High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults. Diabetes Care. DOI:10.2337/dc19-0100.

· Chatterjee P, Lim W L, Shui G, et al. Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study[J]. Journal of Alzheimers Disease, 2016, 50(3):887-894.

· Begum H, Li B, Shui G, et al. Discovering and validating between-subject variations in plasma lipids in healthy subjects[J]. Scientific Reports, 2016, 6:19139. 

· Shui G, Stebbins J W, Lam B D, et al. Comparative Plasma Lipidome between Human and Cynomolgus Monkey: Are Plasma Polar Lipids Good Biomarkers for Diabetic Monkeys?[J]. Plos One, 2011, 6(5):e19731.

· Shui G, Lam S M, Stebbins J, et al. Polar lipid derangements in type 2 diabetes mellitus: potential pathological relevance of fatty acyl heterogeneity in sphingolipids[J]. Metabolomics, 2013, 9(4):786-799.

· Chua C P, Shui G, Cazenavegassiot A, et al. Changes in Plasma Lipids during Exposure to Total Sleep Deprivation[J]. Sleep, 2015, 38(11).

· Chua E C, Shui G, Lee I T, et al. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans[J]. Pnas, 2013, 110(35):14468-14473.

tear 泪

brain/temporal cortex 

颞叶皮质

brain 脑

brain/visual cortex

视觉皮层

auto-antigens and antibodies 

自身抗原和抗体

Sebaceous Glands 

皮脂腺

sputum 痰

Hela cells

Hela 细胞

Mesentery

肠系膜