胆固醇代谢

胆固醇（Cholesterol）又称胆甾醇，是一种类脂化合物,系环戊烷多氢菲的衍生物。胆固醇广泛存在于 动物体内,尤以脑及神经组织中最为丰富,在肾、脾、皮肤、肝和胆汁中含量较高。胆固醇是哺乳动物中主要 的甾体类化合物，在基本的细胞生命活动中起到重要作用。

应用方向：

疾病研究：高胆固醇血症、脂肪肝、高血压、糖尿病、阿尔茨海默症

机制研究：胆固醇代谢机制、肝脏功能机制

参考文献：

1. Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation. Cell Metabolism. 2024 Oct 29:S1550-4131(24)00373-5.
2. Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer. Nature Communications. 2024 Jul 12;15(1):5851.
3. Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma. Nature Communications. 2023 Jul 20;14(1):4367.
4. TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene. 2022 Dec;41(50):5385-5396.
5. Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis. Nature Communications. 2022 Feb 10;13(1):791.
6. A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19. Nature Metabolism. 2021 Jul;3(7):909-922.
7. Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing. Journal of Lipid Research. 2019 Oct;60(10):1765-1775.