氧化胆固醇
氧化胆固醇是胆汁酸、类固醇激素、维生素 D3 和其他炎症和其他疾病状态的生物活性标志物发展的中间体。氧甾醇是甾醇的氧化产物，是与某些疾病相关的生物活性中间体，需要进一步研究以了解它们在疾病发病机制中的作用。氧甾醇有可能影响许多疾病，从心血管疾病（如动脉粥样硬化）到阿尔茨海默病、糖尿病和癌症。它表明，对氧甾醇的进一步研究和理解可能有助于更好地了解疾病。
应用方向：
疾病研究：
动脉粥样硬化
阿尔茨海默病
糖尿病
癌症
机制：
氧甾醇合成途径
Fig. 1 Summarized view of Oxysterol metabolism in mouse liver.
Trends Mol Med. 2016 Jul;22(7):594-614.
|
Oxysterols database |
|||
|
No. |
Name |
No. |
Name |
|
1 |
22-hydroxycholesterol |
8 |
4α-hydroxycholesterol |
|
2 |
24-hydroxycholesterol |
9 |
7α,27-Dihydroxycholesterol |
|
3 |
27-hydroxycholesterol |
10 |
7α,24(S)-Dihydroxycholesterol |
|
4 |
25-hydroxycholesterol |
11 |
7β,27-Dihydroxycholesterol |
|
5 |
7β-hydroxycholesterol |
12 |
24(S),27-Dihydroxycholesterol |
|
6 |
4β-hydroxycholesterol |
13 |
24S,25-Epoxycholesterol |
|
7 |
7α-Hydroxycholesterol |
…… |
…… |
参考文献：
- Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation. Cell Metabolism. 2024 Oct 29:S1550-4131(24)00373-5.
- Prochownik EV, Li Y. Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer. Nature Communications. 2024 Jul 12;15(1):5851.
- Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma. Nature Communications. 2023 Jul 20;14(1):4367.
- A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19. Nature Metabolism. 2021 Jul;3(7):909-922.
- Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing. Journal of Lipid Research. 2019 Oct;60(10):1765-1775.
