类花生酸

我们提供从微生物流体到微量哺乳动物组织以及其他小生物(如秀丽隐杆线虫等)的内源性类二十烷酸的覆盖范围广泛的分析和定量服务.

类花生酸(Eicosanoids)是指一组主要来自花生四烯酸(arachidonic acids,AA)或二十二碳六烯酸 (docosahexaenoic acid,DHA)、二十碳五烯酸(eicosapentaenoic acid,EPA)、等其他多不饱和脂 肪酸通过脂氧合酶(lipoxygenase,LOX),环氧合酶(cyclooxygenase,COX)和细胞色素P450环氧化 酶(cytochrome P450 epoxygenase,CYP450)三个途径合成的具有生物活性的脂质介质。广泛存在于体 液和组织中,调节体内众多生理和病理过程。

应用方向:

疾病研究:炎症、免疫系统疾病、心血管、中枢神经系统疾病、癌症等

机制研究:花生四烯酸代谢、亚油酸代谢、类花生酸生物合成机制及类花生酸生物学功能

 

各类类花生酸的离子色谱图

 

 

参考文献:

 

  1. Fat-1 ameliorates MAFLD and atherosclerosis through promoting the nuclear localization of PPARα in hamsters. Research.2024.
  2. Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin. SCIENCE CHINA Life Sciences. 2024 Jun;67(6):1226-1241.
  3. Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn's Disease. Journal of Crohn's and Colitis. 2020 Nov 7;14(11):1581-1599.