类花生酸

类花生酸（Eicosanoids）是指一组主要来自花生四烯酸（arachidonic acids，AA）或二十二碳六烯酸 （docosahexaenoic acid，DHA）、二十碳五烯酸（eicosapentaenoic acid，EPA）、等其他多不饱和脂 肪酸通过脂氧合酶（lipoxygenase，LOX），环氧合酶（cyclooxygenase，COX）和细胞色素P450环氧化 酶（cytochrome P450 epoxygenase，CYP450）三个途径合成的具有生物活性的脂质介质。广泛存在于体 液和组织中,调节体内众多生理和病理过程。

疾病研究：炎症、免疫系统疾病、心血管、中枢神经系统疾病、癌症等

机制研究：花生四烯酸代谢、亚油酸代谢、类花生酸生物合成机制及类花生酸生物学功能

各类类花生酸的离子色谱图

参考文献：

Li N, Liu JY, Qiu H, Harris TR, Sirish P, Hammock BD, et al. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congest Heart Fail. 2011; 17(1): 42-6.

Zhang X, Yang N, Ai D, Zhu Y. Systematic metabolomic analysis of eicosanoids after omega-3 polyunsaturated fatty acid supplementation by a highly specific liquid chromatography-tandem mass spectrometry-based method. J Proteome Res. 2015; 14(4): 1843-53.

Lam SM, Wang Z, Li J, Huang X, Shui G. Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival. Redox biology. 2017; 12: 967-77.