高覆盖率靶向脂质组学

脂质组学的目标在于建立整个细胞或组织内的所有脂质的综合脂质图谱，已成为联系脂质生物学、技术和医学的一门独立学科。近期在脂质组学研究领域的发展风潮主要归功于分析技术的进步，特别是用于定性和定量细胞脂质组中一系列众多脂质种类的新型质谱和色谱仪器的发展（Lam SM et al., 2013 and 2017）。在中科脂典，我们提供多样化的脂质定量分析服务，涵盖了无与伦比生物脂质组的范围，包含了超过10,000种的脂质及其衍生物。
       对于只含有痕量脂质的人类泪液的脂质组学描述的署名工作中，我们的脂质组学技术的能力得到了证实。我们关于人类泪液的脂质组学的研究在Journal of Lipid Research上发表了一系列的论文(Lam SM et al., 2014, 2014, 2014) 并被ASBMB TODAY推荐。此外，我们对血清、血浆、尿液、牛奶等各种生物体液以及不同类型的生物组织和器官(Shui G et al., 2012; Wang W et al., 2012; Chua EC et al., 2013; Nguyen LN et al., 2014)脂质组分析有着丰富的经验。更多的详细信息，请参阅我们的脂质组服务介绍视频（视频链接）。凭借我们在脂质研究领域的丰富经验，我们还为感兴趣的客户提供有关选择脂质分析覆盖率选择的咨询服务以便最好地满足客户需求。

- 磷脂 Phospholipids: 磷脂酰胆碱PC, 磷脂酰乙醇胺PE, 磷脂酰丝氨酸PS, 磷脂酰肌醇PI, 磷脂酰甘油PG, 甘油磷脂酸PA,双磷脂酰甘油CL, 溶血磷脂酸LBPA, 溶血磷脂酰胆碱LPC, 溶血磷脂酰乙醇胺LPE, 溶血磷脂酰丝氨酸LPS, 溶血磷脂酰肌醇LPI, 溶血甘油磷脂酸LPA
- 鞘脂 Sphingolipids : 鞘磷脂SM, 神经酰胺Cer, 鞘氨醇Sph, 1－磷酸鞘氨醇S1P, 葡糖神经酰胺GluCer, 半乳糖神经酰胺GalCer, 糖脂SL,乳糖神经酰胺LacCer, 神经节苷脂GM3, Gb3, etc;
·  谷甾醇，菜油甾醇等其他甾醇other sterols including sitosterol, campesterol, etc;
- 甘油酯 Glycerol lipids: 甘油三酯/甘油二酯/单甘酯TAG/DAG/MAG profiles
- 蜡酯 Wax ester profiles
- 糖脂 Glycolipid profiles: 单/半乳糖二酰甘油/双半乳糖二酰甘油MGDG/DGDG profiles, 单酰化磷脂酰肌醇甘露糖苷/单酰化磷脂酰肌醇二甘露糖苷AC1PIM1/AC1PM2 profiles
 

Reference

Lam SM, Shui G. Lipidomics as a principal tool for advancing biomedical research. Journal of genetics and genomics 2013;40(8):375-90.

Lam SM, Tian H, Shui G. Lipidomics, en route to accurate quantitation. Biochim Biophys Acta. 2017.

Lam SM, Tong L, Duan X, Petznick A, Wenk MR, Shui G. Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles. J Lipid Res. 2014;55(2):289-98.

Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, et al. Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. J Lipid Res. 2014;55(2):299-306.

Lam SM, Tong L, Duan X, Acharya UR, Tan JH, Petznick A, et al. Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction. J Lipid Res. 2014;55(9):1959-69.

Shui G, Bendt AK, Jappar IA, Lim HM, Laneelle M, Herve M, et al. Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice. EMBO Mol Med. 2012;4(1):27-37.

Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, et al. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 2012;18(2):235-43.

Chua EC, Shui G, Lee IT, Lau P, Tan LC, Yeo SC, et al. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci U S A. 2013;110(35):14468-73.

Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014;509(7501):503-6.