Bridging Metabolome and Health

 Mice (小鼠/大鼠)

brain (大脑)

· Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.

· Lam S M, Wang R, Miao H, et al. An integrated   method for direct interrogation of sphingolipid homeostasis in the heart and   brain tissues of mice through postnatal development up to reproductive   senescence[J]. Analytica Chimica Acta, 2018.

· Chan R B, Oliveira T G, Cortes E P, et al. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.[J]. Journal of Biological Chemistry, 2012, 287(4):2678-88. 

· Lim W L, Lam S M, Shui G, et al. Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.[J]. Neurobiology of Aging, 2013, 34(9):2217-2224.

· Long N N, Ma D, Shui G, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid[J]. Nature, 2014, 509(7501):503.

· Jenner A M, Lim W L F, Ng M P E, et al. The effect of APOE, genotype on brain levels of oxysterols in young and old human APOE, ε2, ε3 and ε4 knock-in mice[J]. Alzheimers & Dementia the Journal of the Alzheimers Association, 2010, 6(4):S255-S256.

· Oliveira T G, Chan R B, Tian H, et al. Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2010, 30(49):16419-28.

· Lee L H, Shui G, Farooqui A A, et al. Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?[J]. Int J Neuropsychopharmacol, 2009, 12(7):953-964.

· Sharman M J, Shui G, Fernandis A Z, et al. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.[J]. Journal of Alzheimers Disease Jad, 2010, 20(20):105-11.

· Zhang F, Wang Y, Wang T, Yao L, Lam SM, Huang X, Fan J, Wang Q, Liu L, Jiang Y, Zhang H, Shi L, Yu M, Shui G, Wang Y, Gao F, Zhang X, Xu Z.  cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain developmentPNAS. 2018, 115(40):E9449-E9458.

brain/prefrontal cortex

前额皮质

brain/cortical neurons 

皮质神经元

brain/nigrostriatal 

黑质纹状体

brain/caudal medulla oblongata

尾髓延髓

brain/hippocampus

海马区

brain/striatum

纹状体

heart 心脏

livers 肝脏

 

lung 肺

plasma 血浆

sebaceous glands 

皮脂腺

adipose 脂肪组织

· Liang XJ, Tao C, Pan JF, Zhang LI,Liu L, Zhao Y, Fan YP, Cao CW,Liu JL, Zhang J, Lam SM, Shui G, Jin WZ, Li W, Zhao JG, Li K, Wang YF. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. Protein & Cell. (2020).

· Lin-Hu Quan, Chuanhai Zhang, Meng Dong, Jun Jiang, Hongde Xu, Chunlong Yan, Xiaomeng Liu, Huiqiao Zhou, Hanlin Zhang, Li Chen, Fei-Liang Zhong, Zhao-Bo Luo, Sin-Man Lam, Guanghou Shui, Donghao Li, Wanzhu Jin. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2019, doi:10.1136

· Liu L, Jiang Q, Liu G. Abstract 406: Adipose-Specific Deletion of SEIPIN/BSCL2 Results in Progressive Lipodystrophy[J]. Arterioscler Thromb Vasc Biol, 2014.

· Si X, Shang W, Zhou Z, et al. Gama-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and SCFAs.[J]. Journal of Agricultural & Food Chemistry, 2018, 66(4).

· Liu Z, Lim C Y, Su M Y, et al. Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations.[J]. Journal of Endocrinology, 2013, 219(2):131-43.

· Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun.2018, 15;9(1):1916.

· Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.

embryonic fibroblasts 

胚胎成纤维细胞

muscles 肌肉

mammary gland 

乳腺

Intestine  肠道

· Liu RQ, Qiao SH, Shen WS, Liu Y, Lu Y, Huang LY, Guo Z, Gong JF, Shui G, Li Y, Zhu WM. Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn’s Disease. J Crohns Colitis. 2020. DOI: 10.1093/ecco-jcc/jjaa086.

· Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.