中科脂典-果蝇

Drosophila 果蝇

fat cells

脂肪细胞

· L Ding ， X Yang ， H Tian , et al.Seipin regulates lipid homeostasis by ensuring calcium‐dependent mitochondrial metabolism.The EMBO Journal,2018,e97572.

· Yan Y, Wang H, Hu M, et al. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila[J]. Developmental Cell, 2017, 43(1):99.

· Wei F, Lam S M, Xin J, et al. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition[J]. Plos Genetics, 2017, 13(3):e1006664.

· Liu Y, Wang W, Shui G, et al. CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway[J]. Plos Genetics, 2014, 10(3):e1004172.

· Guan X L, Cestra G, Shui G, et al. Biochemical membrane lipidomics during Drosophila development.[J]. Developmental Cell, 2013, 24(1):98-111.

brain 大脑

Huang Y, Huang S, Lam S M, et al. Acsl, the Drosophila ortholog of intellectual disability-related ACSL4, inhibits synaptic growth by altered lipids[J]. Journal of Cell Science, 2016, 129(21):4034.

salivary gland cells

唾液腺细胞

· Xiao Yang, Jingjing Liang, Long Ding, Xia Li, Sin-Man Lam, Guanghou Shui, Mei Ding, Xun Huang. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLOS. 2019, doi:10.1371

· Liu Y, Ji Y, Li X, Shui G, Huang X. Lipid storage regulator CdsA is essential for Drosophila metamorphosis. J Genet Genomics. 2019, 46(4):231-234.

· Tian Y, Bi J, Shui G, et al. Tissue-Autonomous Function of, Drosophila Seipin, in Preventing Ectopic Lipid Droplet Formation[J]. Plos Genetics, 2011, 7(4):e1001364.

S2 cells

S2细胞

· Wang W, Xin J, Yang X, Lam SM, Shui G*, Wang Y, Huang X. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Biochim Biophys Acta Mol Cell Biol Lipids. 2019, 1864(2):168-180.

fat body

脂肪体

· Lam SM#, Zhou TX#, Li J#, Zhang SH, Chua GH, Li BW, Shui G*. A robust, integrated platform for comprehensive analyses of acyl-coenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development. Science Bulletin 2020,

· Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G, Huang X.EMBO J. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 2018,545

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