Bridging Metabolome and Health
Drosophila 果蝇
fat cells
脂肪细胞
L Ding , X Yang , H Tian , et al.Seipin regulates lipid homeostasis by ensuring calcium‐dependent mitochondrial metabolism.The EMBO Journal,2018,e97572.
Yan Y, Wang H, Hu M, et al. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila[J]. Developmental Cell, 2017, 43(1):99.
Wei F, Lam S M, Xin J, et al. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition[J]. Plos Genetics, 2017, 13(3):e1006664.
Liu Y, Wang W, Shui G, et al. CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway[J]. Plos Genetics, 2014, 10(3):e1004172.
Guan X L, Cestra G, Shui G, et al. Biochemical membrane lipidomics during Drosophila development.[J]. Developmental Cell, 2013, 24(1):98-111.
brain 大脑
Huang Y, Huang S, Lam S M, et al. Acsl, the Drosophila ortholog of intellectual disability-related ACSL4, inhibits synaptic growth by altered lipids[J]. Journal of Cell Science, 2016, 129(21):4034.
salivary gland cells
唾液腺细胞
Xiao Yang, Jingjing Liang, Long Ding, Xia Li, Sin-Man Lam, Guanghou Shui, Mei Ding, Xun Huang. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLOS. 2019, doi:10.1371
Liu Y, Ji Y, Li X, Shui G, Huang X. Lipid storage regulator CdsA is essential for Drosophila metamorphosis. J Genet Genomics. 2019, 46(4):231-234.
Tian Y, Bi J, Shui G, et al. Tissue-Autonomous Function of, Drosophila Seipin, in Preventing Ectopic Lipid Droplet Formation[J]. Plos Genetics, 2011, 7(4):e1001364.
S2 cells
S2细胞
Wang W, Xin J, Yang X, Lam SM, Shui G*, Wang Y, Huang X. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Biochim Biophys Acta Mol Cell Biol Lipids. 2019, 1864(2):168-180.
Lam SM#, Zhou TX#, Li J#, Zhang SH, Chua GH, Li BW, Shui G*. A robust, integrated platform for comprehensive analyses of acyl-coenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development. Science Bulletin 2020,
Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G, Huang X.EMBO J. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 2018,545
fat body
脂肪体
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